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PRODID:https://murmitoyen.com/events/vanille/udem/
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UID:69e1b5bdc5f73
DTSTAMP:20260417T002325
DTSTART:20121115T113000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20121115T130000
URL:https://murmitoyen.com/events/vanille/udem/detail/156840
LOCATION:Université de Montréal - Pavillon Claire-McNicoll\, 2900\, chemi
 n de la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Conférence du Professeur Marc Gingras (Marseille)
DESCRIPTION:Titre: Degradable Dendrimers. Synthesis and Usefulness in Drug 
 Delivery.Cette conférence sera prononcée en anglais par le professeur Ma
 rc Gingras du Centre Interdisciplinaire de Nanoscience à Marseilles (CINa
 M) affilié à l'Université Aix-Marseille (France). Ce dernier sera à Mo
 ntréal dans le cadre d'une mission inter-universitaire de plusieurs semai
 nes.Résumé : In the last decade\, a new stage was set in the chemistry o
 f dendrimers: their degradation. It happened after many efforts to assembl
 e them in an efficient manner. The degradability of dendrimers is a modern
  topic in the era of green chemistry and environmental concerns. The curre
 nt progress in this field suggests highly important uses to come\, especia
 lly in life sciences\, in nanosciences and in materials chemistry. Dendrim
 ers are well-defined\, discrete macromolecules with a high degree of molec
 ular uniformity and monodispersity. Several features such as multifunction
 ality\, multivalency effects\, adhesive properties or molecular recognitio
 n and encapsulation make them attractive for drug delivery systems. This w
 ork will focus on the selection and the optimization of specific structura
 l elements in order to offer a satisfactory compromise between structure-p
 roperties relationships (water-solubility\, biocompatibility\, reduced tox
 icity and enzymatic degradability). A structural and functional strategy e
 nlightened a multilayer approach of components for optimizing the properti
 es. The synthesis of new symmetric or non-symmetric dendritic architecture
 s bearing drugs in a covalent way were sought toward possible uses in mono
 - or in polytherapy. Studies concerning the enzymatic degradation of some 
 dendritic prodrugs will be described. In vitro studies highlighted a “mu
 ltiplicity effect” and the influence of several structural parameters mo
 dulating drug delivery processes.Information supplémentaire
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TZID:America/Montreal
X-LIC-LOCATION:America/Montreal
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