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UID:69e17daadff8f
DTSTAMP:20260416T202410
DTSTART:20130213T110000
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20130213T123000
URL:https://murmitoyen.com/events/vanille/udem/detail/144090
LOCATION:Université de Montréal - Pavillon J.-Armand-Bombardier\, 5155\, 
 chemin de la rampe \, Montréal\, QC\, Canada\, H3T 2B2
SUMMARY:Conférence du Professeur Thomas Laue (New Hampshire)
DESCRIPTION:Titre : Proximity Energy Framework for Biological Systems.La co
 nférence sera prononcée par le professeur Thomas Laue du Département d
 es sciences moléculaires\, cellulaires et biomédicales de l'University o
 f New Hampshire. Elle sera donnée en anglais. Résumé : In living syste
 ms proteins function in concentrated and complicated environments. Thus\, 
 while the reductionist approach of characterizing the structures and funct
 ions of isolated proteins will remain necessary\, it is essential that we 
 have a chemical framework to understand how they behave in vivo. That fram
 ework will tell us what instruments and methods are needed to study protei
 ns in the post-reductionist era. The differences between studying a dilute
  solution of an isolated protein and understanding its behavior in vivo co
 me down to coping with three new characteristics: greater system complexit
 y\, high concentrations and abundant\, heterogeneous surface area. From a 
 thermodynamic standpoint\, the greater complexity means that we must recog
 nize that many protein characteristics are system properties\, and are not
  properties of the protein. Thermodynamically\, high concentrations force 
 us to be comfortable discussing the chemical activity of the protein and n
 ot just its concentration. Finally\, the presence of diverse surfaces in v
 ivo compels us to consider how a protein interacts with those surfaces\, a
 nd the effect of the interaction on its chemical potential. It seems that 
 the combined effects of the system complexity\, high concentration and lar
 ge surface area form a Gordian knot that cannot be understood by inductive
  reasoning. However\, an understanding of colloid and surface chemistry ca
 n guide our understanding of cellular phenomena and\, ultimately\, help 'r
 everse engineer' how biological processes occur. This understanding will h
 elp us when we try to manipulate these processes for scientific or medical
  purposes. First and foremost\, the key to understanding high concentratio
 n colloidal systems is the understanding of the electrostatics of the comp
 onents. Information supplémentaire
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