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DTSTART:20181001T110000
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URL:http://murmitoyen.com/events/vanille/detail/838393-conference-de-chimie
 -avec-la-professeure-olivia-reinaud-de-luniversite-paris-descartes
LOCATION:Université de Montréal - Pavillon Roger-Gaudry\, 2900\, chemin d
 e la Tour\, Montréal\, QC\, Canada\, H3T 1J6
SUMMARY:Conférence de chimie  avec la professeure Olivia Reinaud de l'Univ
 ersité Paris Descartes
DESCRIPTION:Conférence de chimie  avec la professeure Olivia Reinaud de
  l'Université Paris Descartes 
\n 
\nTitre: ‘‘ METAL IONS IN BIOMI
 METIC CAVITIES’’
\n 
\nEndroit : G-715\, Pavillon Roger-Gaudry
\n 

 \nHeure : 11:00 AM
\n 
\nHôte : Prof. Jean-François Masson
\n 
\nRésu
 mé :
\n 
\n Metal ions are essential to life for all organisms. More t
 han 30% of the enzymes present one or more metal ions in their active site
 s. They may have a structuring role vis-à-vis the protein\, they may also
  be key in the recognition of a substrate or of a cofactor\, or they may a
 ct as catalyst for the activation of substrates and small molecules such a
 s water or dioxygen. The knowledge of these metallic systems is an infinit
 e source of inspiration for chemists. The lack of knowledge of their role 
 makes them a subject of fundamental studies essential to the understanding
  of life.
\n 
\n The aim of our work is to design supramolecular systems
  that will mimic both\, the coordination core\, and the hydrophobic pocket
  of a metallo-enzyme active site. Our strategy relies on the synthesis of 
 cavity-based ligands that allow the control of the metal ion micro-environ
 ment\, together with the approach and the binding of guest molecules.
\n 
 
\n Since many years\, we have been developing systems based on the calix
 [6]arene scaffold\, giving rise to the so-called “funnel complexes”. M
 ore recently\, we started to explore metal complexes based on the resorcin
 [4]arene scaffold\, which provides a supramolecular environment different 
 in shape\, rigidity and binding properties\, so-called “Bowl-complexes
 ”. One of our focus is the impact of the second and third coordination s
 pheres provided by the cavities on their hosting properties and redox beha
 vior. Various aspects such as dioxygen activation at a biomimetic mononucl
 ear Cu(I) center\, supramolecular control of of metal ions\, guest covalen
 t capture by a host\, water-soluble receptors\, surface functionalization 
 by mono-layered cavities as well as biomimetic catalysis are developed.
\n
  
\nInformations supplémentaires
\n 
\nAnnonce PDF de la conférence
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